Florence - amazing!
I love Florence. I fell in love with it on my first trip last September and so visited it again in Feb. It has so much to see and do - the art and architecture speak for themselves and the food and wine is fantastic. The locals are so friendly and so patient if you try out your Italian! I don't really go to places for the shopping but the food shopping was great. I also am a little bit old for all night partying, but my kind of partying (until a reasonable midnight) - see below - was perfect.
Insider Tip:Go to the San Lorenzo market, upstairs, to hang out with all the locals at the indoor food hall. Think freshly made pizzas, quality wine stalls, mozzarella stands... And a great buzzing atmosphere, especially at night. Also, the ibikeItaly bike tour into Chianti was a great way to spend a day.