Santiago.
Santiago is a good city to base yourself to reach places like Valparaiso, Easter Island and Mendoza. The Bella Vista is where the nightlife is located with nice restauarants both reasonably and expensively priced. This area also has a good range of bars with a young student feel due to the universities near by. The main problem that the city has is smog. It is quite bad and usually blocks out the picturisc view of the Andes. Overall Santiago is modern large city with always something to do.
Insider Tip:Include a visit to Coffee with legs! Ask the guide on the free walking tour about it!

