Santiago is one of the most organized South American cities. While in Santiago, don't expect the typical caos you maybe find in cities like La Paz. Getting around is very easy if you use the metro. Santiago is a very interesting city in terms of culture due to its recent history. Nightlife in Santiago is unmissable, especially the party called "Miercoles Po". Nevertheless, if you are on a low budget don't expect to eat very well, or get good "menu del dia". Watch out for the contamination.
Insider Tip:Good city to ride in bike.