Santiago is standing a bit in the shadow of the glamorous and populair Buenos Aires. Totally unnecessary! Great and vibrant city with a wide range of affordable (for chilean standards) and creative restaurants, well taken care off museums like the Memorial museum and the Pre-colombian art museum and different neighbourhoods with their own character. The subway and bus system make it easy to get around, the chileans are helpful and hard working.
Insider Tip:The free city tour of this city is really nice and will teach you a lot about the rich history of Chile. My favourite things to do were the climb of the San Christobal hill and a visit to a Cafe con Piernas.