There are many ways to get to Manuel Antonio. The most common is by car or by bus. If you go by public bus, then you'll have to catch a bus from San Jose to Quepos, and then from Quepos to Manuel Antonio. Schedules vary, so it's best to inquire with the bus company. There are other private buses that travel directly from San Jose to Manuel Antonio, and they are: Saragundi Specialty Tours or American VIP Coach Service. The option by air is also available, since the local airline SANSA offers regular flights there.
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