Rome is truly an amazing city no matter your gender, age, or interests. I've been three times now - first time on a study trip, second time on my own, and the previous time with my husband and toddler. Every single time there was something new to see and experience because the city really offers a great variety of, well, everything.
Insider Tip:If you're worried that it's not a kid-friendly city... don't! Our son just turned 2 and we had no trouble having him around with us; it was easy enough to get the stroller around, everyone was smiling and talking to him, and he enjoyed experiencing new things and trying new food.